（なし）

研究室配属(３年生)

1. Yokoyama M, Shiraishi K, Stability evaluation of Gd chelates for macromolecular MRI contrast agents. Magnetic Resonance Materials in Physics, Biology and Medicine, 2020; 3: 527-536.
2. Shiraishi K, Yokoyama M, Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review. Science and Technology of Advanced Materials, 2019; 20: 324-336 .
3. Asakura T, Yokoyama M, Shiraishi K, Aoki K, Ohkawa K, Chemotherapeutic Effect of CD147 Antibody-labeled Micelles Encapsulating Doxorubicin Conjugate Targeting CD147-Expressing Carcinoma Cells. Anticancer Res. 2018; 8:1311-1316.
4. Akai H*, Shiraishi K, Yokoyama, M Yasaka K*, Nojima M,** Inoue Y***, Abe O****, Ohtomo K*****, Kiryu S* (*Department of Radiology, Institute of Medical Science, University of Tokyo, **Division of Advanced Medicine Promotion, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo,***Department of Diagnostic Radiology, Kitasato University School of Medicine,**** Department of Radiology, Graduate School of Medicine, University of Tokyo, ***** International University of Health and Welfare) PEG-poly(L-lysine)-based polymeric micelle MRI contrast agent: Feasibility study of a Gd-micelle contrast agent for MR lymphography. J. Magnetic Resonance Imaging 2018; 47: 238-245.
5. Shiraishi K, Wang Z, Kokuryo D*, Aoki I*, Yokoyama M (*Department of Molecular Imaging and Theranostics, National Institutes for Quantumand Radiological Science and Technology) A polymeric micelle magnetic resonance imaging (MRI) contrast agent reveals blood-brain barrier (BBB) permeability for macromolecules in cerebral ischemia-reperfusion injury., J. Controlled Release 2017; 253: 165-171.
6. Wang Z, Komatsu T, Mitsumura H, Nakata N, Ogawa T, Iguchi Y, Yokoyama M. An Uncovered Risk Factor of Sonothrombolysis: Substantial Fluctuation of Ultrasound Transmittance through the Human Skull. Ultrasonics 2017; 77:168-175.
7. Shiraishi K, Kawano K*, Maitani Y*, Aoshi T**, Ishii KJ**, Sanada Y***, Mochizuki S***, Sakurai K***, Yokoyama M (* Institute of Medicinal Chemistry, Hoshi University, ** Immunology Frontier Center, Osaka University, *** Department of Chemistry and Biochemistry, The University of Kitakyushu) Exploring the relationship between Anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance. J. Controlled Release, 2016;234:59-67.
8. Shiraishi K, Sanada Y*, Mochizuki S*, Kawano K**, Maitani Y**, Sakurai K*, Yokoyama M (*Department of Chemistry and Biochemistry, The University of Kitakyushu, ** Institute of Medicinal Chemistry*) Determination of polymeric micelles'' structural characteristics, and effect of the characteristics on pharmacokinetic behaviors. J. Controlled Release 2015; 203: 77-84.
9. Shiraishi K, Hamano M*, Huili M*, Kawano K* Maitani Y*, Aoshi T**, Ishii KJ**, Yokoyama M (* Institute of Medicinal Chemistry, Hoshi University, **Immunology Frontier Research Center, Osaka University) Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon. J. Controlled Release 2013; 165: 183-190.
10. Sanada Y*, Akiba I*, Sakurai K*, Shiraishi K, Yokoyama M, Mylonas E**, Ohta N**, Yagi N**, ShinoharaY***, Amemiya Y*** (*Department of Chemistry and Biochemistry, The University of Kitakyushu, ** Japan Synchrotron Radiation Research Institute, *** Graduate School of Frontier Sciences, The University of Tokyo) Hydrophobic Molecules Infiltrating into the PEG Domain of the Core/Shell Interface of a Polymeric Micelle: Evidence Obtained with Anomalous Small-Angle X-ray Scattering. Journal of the American Chemical Society 2013; 135: 2574-82.

• 文部科学省科学研究費補助金・学術変革領域研究（A）
  「成高分子と生体分子との弱相互作用を起点とする生体応答の解明」


• 文部科学省科学研究費補助金・基盤研究(B)
  「抗原-抗体結合を反応場とする抗体機能抑制法の開発」


• 文部科学省科学研究費補助金・挑戦研究(萌芽)
  「非免疫原性分子の免疫的な記憶の解明」


• 文部科学省科学研究費補助金･基盤研究（B）
  「高分子造影剤動態解析による脳循環機構の解明と医療応用」


• 文部科学省科学研究費補助金・挑戦研究(萌芽)
  「抗体の多様性に対するシンプリシティの解明」


• がん研究開発費「がんナノテクノロジー研究プラン」


• 文部科学省科学研究費補助金･基盤研究（B）
  「多様な画像モダリティーに対応した高分子造影剤システムの創成」


• 文部科学省科学研究費補助金･新領域研究
  「高分子ミセルキャリヤーの免疫原性制御のためのインターフェース設計」


• がん研究開発費
  「がん組織の特異性を利用したドラッグデリバリーシステム（ＤＤＳ）薬剤の基礎的・臨床的開発に関する研究」


• 新エネルギー・産業技術総合開発機構分子イメージング機器研究開発プロジェクト／新規悪性腫瘍分子プローブの基盤技術開発
  「高分子ミセルキャリアの開発」


• 文部科学省科学研究費補助金・若手研究B
  「化学交換飽和移動法を利用する高感度ＭＲＩ造影剤の開発」


• 文部科学省科学研究費補助金・基盤研究（B）
  「高分子ミセル抗癌剤のＣＥＤ法への応用」

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